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REACT4KIDS

Unité Inserm U1234 (PANTHER)

Faculté de Médecine, Rouen

 

Membres

Dr. Souleymane Abdoul-Azize
Pr. Jean-Pierre Vannier
Pr. Olivier Boyer

 

Thématique de recherche générale en Oncopédiatrie

• Physiopathologie, autoimmunité, maladies neuromusculaires, et thérapies régénératrices
• Mécanismes de résistance aux glucocorticoïdes dans la leucémie aigüe lymphoblastique
• Méthode : Signalisation cellulaire, calcium, méthodes de biologie cellulaire et moléculaire, cryométrie en flux

 

Collaborations

CHU de Rouen

 

Publications

Integration of Ca2+ signaling regulates the breast tumor cell response to simvastatin and doxorubicin.
Abdoul-Azize S, Buquet C, Li H, Picquenot JM, Vannier JP.
Oncogene. 2018 Sep;37(36):4979-4993.

Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation.
Abdoul-Azize S, Dubus I, Vannier JP.
Oncotarget. 2017 Apr 18;8(16):27339-27352

Pyr3, a TRPC3 channel blocker, potentiates dexamethasone sensitivity and apoptosis in acute lymphoblastic leukemia cells by disturbing Ca(2+) signaling, mitochondrial membrane potential changes and reactive oxygen species production.
Abdoul-Azize S, Buquet C, Vannier JP, Dubus I.
Eur J Pharmacol. 2016 Aug 5;784:90-8.

Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways.
Petit C, Gouel F, Dubus I, Heuclin C, Roget K, Vannier JP.
BMC Cancer. 2016 Sep 22;16(1):746.

Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance.
Letouzey M, Penther D, Roche-Lestienne C, Nelken B, Devoldère C, Vannier JP, Schneider P.
Ann Hematol. 2015 Feb;94(2):187-93.

Direct effect of bevacizumab on glioblastoma cell lines in vitro.
Simon T, Coquerel B, Petit A, Kassim Y, Demange E, Le Cerf D, Perrot V, Vannier JP.
Neuromolecular Med. 2014 Dec;16(4):752-71

Importance of ERK activation in As2O3-induced differentiation and promyelocytic leukemia nuclear bodies formation in neuroblastoma cells.
Petit A, Delaune A, Falluel-Morel A, Goullé JP, Vannier JP, Dubus I, Vasse M.
Pharmacol Res. 2013 Nov;77:11-21.

 

Contact

bontasso@yahoo.fr